The museum features the Crossroads Gallery, which includes exhibits and interactive kiosks highlighting the history of southeast Missouri, including: The Land and Waters; First Voices; First Peoples; Frontiers and Empires; River and Rail; North and South; Subsistence to Agribusiness; Expressions of Faith; and Change through Education.
Exhibitions in the museum’s 1,900 square-foot gallery feature works by local, regional, national and international artists. The museum offers educational classes related to the museum’s mission, collections, permanent and changing exhibitions.